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R&D Highlights

The results of the NWO co-funded COAST R&D program have been published in the following high-impact peer-reviewed journals (listed per project):

HYPERformance Liquid Chromatographyhyperformance liquid chromatography

  • 'Mucin-based stationary phases as tool for the characterization of drug-mucus interaction', Andrea F.G. Gargano, Michael Lämmerhofer, Hans Lönn, Peter J. Schoenmakers and Tomas Leek, Journal of Chromatography A, 1351 (2014) 70–81 doi:10.1016/j.chroma.2014.05.031.
  • 'A new measure of orthogonality for multi-dimensional chromatography', Michelle Camenzuli and Peter Schoenmakers, Analytica Chimica Acta, 838 (2014) 838 93-101 doi:10.1016/j.aca.2014.05.048.
  • 'Comprehensive Two-Dimensional Liquid Chromatography with Stationary-Phase-Assisted Modulation Coupled to High-Resolution Mass Spectrometry Applied to Preteome Analysis of Saccharomyces cerevisiae', Rudy J. Vonk, Andrea F.G. Gargano, Ekaterina Davydova, Henk L. Dekker, Sebastiaan Eeltink, Leo J. de Koning, Peter J. Schoenmakers, Analytical chemistry, 87 (2015) 387 - 5394 doi:10.1021/acs.analchem.5b00708
  • Switching solvent and enhancing analyte concentrations in small effluent fractions using in-column focusing', H.C. van de Ven, A.F.G. Gargano, Sj. van der Wal, P.J. Schoenmakers, Journal of Chromatography, 2015, doi:10.1016/j.chroma.2015.11.082

Diffusional nanoprobes for multi-length scale material characterisation (DINAMISCH)

  • 'Complex coacervate complex micelles as diffusional nanoprobes', Nadia Bourouina, Martien A. Cohen Stuart and J. Mieke Kleijn, Soft Matter, 10 (2014) 320–331 doi:10.1039/C3SM5224H5.
  • 'NMR nanoparticle diffusometry in hydrogels: enhancing sensitivity and selectivity', Daan W. de Kort, John P. M van Duynhoven, Freek J.M Hoeben, Henk M. Janssen and Henk Van As,  Analytical Chemistry, 86 (2014) 9229-35 doi:10.1 021/ac502211.
  • 'Nanoparticle diffusometry for quantitative assessment of submicron structure in food biopolymer networks: a review', Daan W. de Kort, John P.M. van Duynhoven, Henk Van As and François Mariette, Trends in Food Science & technology, 42 (2014) 13-26 doi:10.1016/j.tifs.2014.11.003.
  • 'Scaling Behavior of Dendritic Nanoparticle Mobility in Semidilute Polymer Solutions', Daan W. De Kort, Wolf H. Rombouts, Freek J.M. Hoeben, Henk M. Janssen, Henk van As, John P.M. van Duynhoven, Marcomolecules, 48 (2015) 7585–7591 doi:10.1021/acs.macromol.5b01530
  • 'Complex Coacervate Core Micelles with Spectroscopic Labels for Diffusometric Probing of Biopolymer Networks', Nadia Bourouina, Daan W. de Kort, Freek J.M. Hoeben, Henk M. Janssen, Henk van As, Johannes Hohlbein, John P.M. van Duynhoven, J. Mieke de Kleijn, Langmuir, 31 (2015) 12635 - 12643 doi:10.1021/acs.langmuir.5b03496
  • '19F Labelled Polyion Micelles as Diffusional Nanoprobes', Daan W. de Kort, Freek J.M. Hoeben, Henk M. Janssen, N. Bourouina, J. Mieke de Kleijn, John P. M. van Duynhoven, Henk van As, In book: Magnetic Resonance in Food Science: Defining Food by Magnetic Resonance, Publisher: RSC Publishing, 2015, Editors: Fransesco Capozzi, Luca Laghi, Peter S. Belton, pp. 109 - 119. doi:10.1039/9781782622741-00109
  • 'Yielding and flow of cellulose microfibril dispersions in the presence of a charged polymer', Daan W. de Kort, Sandra J. Veen, Henk Van As, Daniel Bonn, Krassimir P. Velikov, John P.M. van Duynhoven, Soft Matters, doi:10.1039/c5sm02869h 
  • 'Estimating microstructural length scales in k-carrageenan hydrogels by PFG NMR nanoprobe diffusometry', Daan W. de Kort, Henk van As, John P. M. van Duynhoven. Magnetic Resonsnace in Food Science 2016 Proceedings, doi:10.1255mrfs.14

Enhanced bioresolution and miniaturization of surface plasmon resonance optical sensing (SPRing).

  • 'Surface characterization and antifouling properties of nanostructured gold chips for imaging surface plasmon resonance biosensing', Sweccha Joshi, Paola Pellacani, Teris  A. van  Beek, Han Zuilhof and Michel W.F. Nielen, Sensors and Actuators B: Chemical, 209 (2015) 505-514 doi:10.1016/j.snb.2014.11.133.
  • 'Multiplex surface plasmon resonance biosensing and its transferability towards imaging nanoplasmonics for detection of mycotoxins in barley', Sweccha Joshi, Anna Segarra-Fas, Jeroen Peters, Han Zuilhof, Teris A. van Beek and Michel W.F. Nielen, Analyst, 141 (2016) 1307 - 1318 doi:10.1039/c5an02512e
  • 'On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples', Dina Lakayan, Rob Haselberg, Wilfried M.A. Niessen, Govert W. Somsen and Jeroen Kool, Journal of Chromatography A, 452 (2016) 81-88, doi:10.106/j.chroma.2016.05.033
  • 'Analysis of Mycotoxins in Beer Using a Portable Nanostructured Imaging Surface Plasmon Resonance Biosensor', Sweccha Joshi, Rumaisha M. Annida, Han Zuilhof, Teras A. van Beekand Michel W. F. Nielen, Journal of Agricultural and Food Chemistry, 64 (2016) 8263-8271 doi:10.1021/acs.jafc.6b04106
  • 'Biochip Spray: Simplified Coupling of Surface Plasmon Resonance Biosesning and Mass Spectrometry', Sweccha Joshi, Han Zuilhof, Teris A. van Beek, Michel W. F. Nielen, Analytical Chemistry, 89 (2017), 1427 - 1432, doi:10.1021/acs.analchem.6b04012 

Analysis of large data sets by enhanced robust techniques (ALBERT)

  • 'Breaking with trends in pre-processing?', J. Engel, J. Gerretzen, E. Szymańska, J.J Jansen, G. Downey and L. Blanchet and L.M.C. Buydens, Trends in Analytical Chemistry, 50 (2013) 96–106 doi:10.1016/j.trac.2013.04.015.
  • 'Data size reduction for the classification of breath and air samples using multicapillary column-ion mobiliyu spectrometry', Ewa Szymańska, Emma Brodrick, Mark Williams, Antony N. Davies, Henk-Jan van Manen and Lutgarde M.C. Buydens,  Anal. Chem. 87 (2015) 869-875 doi:10.1021/ac503857y.
  • 'A novel approach for analyzing gas chromatography-mass spectrometry/ olfactometry data', Jan Gerretzen, Lutgarde M.C. Buydnens, Ariette O. Tromp - van den Beukel, Elisabeth Koussissi, Eric R. Brouwer, Jeroen J. Jansen, Ewa Szymańska, Chemometrics and Intelligent Laboratory Systems, 146 (2015) 290-296 doi:10.1016/j.chemolab.2015.05.027
  • 'Simple and Effective Way for Data Preprocessing Selection Based on Design of Experiments', Jan Gerretzen, Ewa Szymańska, Jeroen J. Jansen, Jacob Bart, Henk-Jan van Manen, Edwin R. van den Heuvel and Lutgarde M.C. Buydens, Analytical Chemistry, 87 (2015) 12096-12103 doi:10.1021/acs.analchem.5b02832
  • 'Chemometrics and qualitative analysis have a vibrant relationship', Ewa Szymańska, Jan Gerretzen, Jasper Engel, Brigitte Geurts, Lionel Blanchet, Lutgarde M.C. Buydens, Trends in Analytical Chemistry, 69 (2015) 34-51 doi:10.1016/j.trac.2015.02.015
  • 'Increasing conclusiveness of clinical breath analysis by improved baseline correction of multi capillary column - ion mobility spectrometry (MCC-IMS) data', Ewa Szymańska, Gerjen H. Tinnevelt, Emma Brodrick, Mark Williams, Antony N. Davies, Henk-Jan van Manen, Lutgarde M.C. Buydens, Journal of Pharmaceutical and Biomedical Analysis (2016) doi:10.1016/j.jpba.2016.01.052
  • 'Chemometrics for ion mobility spectrometery data: recent advances and future prospects', Ewa Szymańska, Antony N. Davies and Lutgarde M. C. Buydens, Analyst, 141 (2016), 5689-5708 doi: 10.1039/c6an01008c 


  • 'Retention time prediction in temperature-programmed, comprehensive two dimensional gas chromatography: Modeling an error assessment', Andrei Barcaru, Andjoe Androedh-Sampat, Hans-Gerd Janssen and Gabriel Vivó-Truyols, Journal of Chromatography, 1368 (2014) 190-198 doi: 10.1016/j.chroma.2014.09.055.
  • 'Post-polymerization photografting on methacrylate-based monoliths for separation of intact proteins and protein digests with comprehensive two-dimensional liquid chromatography hyphenated with high-resolution mass spectrometry', Rudy Vonk, Sander Wouters, Andrei Barcaru, Gabriel Vivó-Truyols, Sebastian Eeltink, Leo de Koning and Peter Schoenmakers, Anal Bioanal Chem. 407 (2015) 3817-29. doi: 10.1007/s00216-015-8615-4.
  • 'Use of Bayesian Statistics for Pairwise Comparison of Megavariate Data Sets: Extracting Meaninful Differences between GCxGC-MS Chromatograms Using Jensen-Shannon Divergence', Andrei Barcaru and Gabriel Vivó-Truyols, Analytical Chemistry 88 (2016) 2096-2104, doi:10.1021/acs.analchem.5b03506
  • 'Robust Bayesian Algorithm for Targeted Compound Screening in Forensic Toxicology', Michael Woldegebriel, John Gonsalves, Arian van Asten and Gabriel Vivó-Truyols, Analytical Chemistry 88 (2016) 2421-2430, doi:10.1021/acs.analchem.5b04484
  • 'A New Bayesian Approach for Estimating the Presence of a Suspected Compound in Routine Screening Analysis', Michael Woldegebriel and Gabriel Vivó-Truyols, Analytical Chemistry 88 (2016) 9843-9849, doi: 10.1021/acs/analchem.6b03026

Miniaturizing mass spectrometry, bringing mass spectrometry to daily life

  • 'Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System', Sarfaraz U. A. H. Syed, Gert B. Eijkel, Piet Kistemaker, Shane Ellis, Simon Maher, Donald F. Smith and Ron M. A. Heeren , J Am Soc Mass Spectrom 25 (2014) 1780-1787 doi:10.1007/s13361-014-0958-0.
  • 'A micropixelated ion-imaging detector for mass resolution enhancement of a QMS instrument', Sarfaraz U. A. H. Syed, Gert B. Eijkel, Simon Maher, Piet Kistemaker, Stephen Taylor and Ron M. A. Heeren , Anal Bioanal Chem 407 (2014) 2055-2062 doi:10.1007/s00216-014-8158-0.
  • 'Direct Ion Imaging Approach for Investigation of Ion Dynamics in Multipole Ion Guides', Sarfaraz U. A. H. Syed, Simon Maher,  Gert B. Eijkel, Shane R. Ellis,  Fred Jjunju, Stephen Taylor and Ron M. A. Heeren, Analytical Chemistry, 87 (2015) 3714-3720 doi: 10.1021/ac5041764.

Real-time in vivo measurement of semi-volatiles in air/breath

  • 'Comprehensive Data Scientific Procedure for Enhanced Analysis and Interpretation of Real-Time Breath Measurements in In Vivo Aroma-Release Studies', Ewa Szymanska, Phil A. Brown, Aldo Ziere, Sara Martins, Max Batenburg, Frans J. M. Harren and Lutgarde M. C. Buydens, analytical chemistry, 87 (2015) 10338-10345 doi:10.1021/acs.analchem.5b02420

Localized Spectroscopy of Polymers by Solid-State NMR

  • ‘High resolution triple resonance micro magic angle spinning NMR spectroscopy of nanoliter sample volumes’, J. Ole Brauckmann, J.W.G. (Hans) Janssen and Arno P.M. Kentgens, Phys.Chem.Chem.Phys., 18 (2016) 4902-4910 doi: 10.1039/c5cp07857a

Analysis of biomolecules on surfaces [BioSurf]

  • 'Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials', Charlène B.S.S. Danoux, David C. Bassett, Ziryan Othman, Ana I. Rodrigues, Rui L. Reis, Jake E. Barralet, Clemens A. van Bitterwijk and Pamela Habibovic, Acta Biomaterialia, 17 (2015) 1-15 doi: 10.1016/j.actbio.201.02.003

Next generation ambient imaging mass spectrometry for (bio)polymers and smart materials [POLYIMAGE]

  • 'Ambient Characterization of Synthetic Fibers by Laser Ablation Electrospray Ionization Mass Spectrometry’, Fred A.M.G. van Geenen, Maurice C.R. Franssen, Anton H.M. Schotman, Han Zuilhof, and Michel W.F. Nielen, Analytical Chemistry, Article ASAP

Making Analytically Incompatible Approaches Compatible [MANIAC)

  • 'Characterization of synthetic dyes by comprhensive two-dimensional liquid chromatography combining ion-exchange chromatography and fast ion-pair reversed-phase chromatography', Bob W.J. Pirok, Jitske Knip, Maarten R. van Bommel, Peter J. Schoenmakers, Journal of Chromatography A, 1436 (2016) 141 - 146 doi:10.1016/j.chroma.2016.01.070
  • 'Program for the interpretive optimization of two-dimensional resolution', Bob W.J. Pirok, Sandra Pous-Torres, Cassandra Ortiz-Bolsico, Gabriel Vivo-Truyols, Peter J. Schoenmakers, Journal of Chromatography A, 1450 (2016) 26-37 doi:10.1016/j.chroma.2016.04.061
  • 'Size-exclusion chromatography using core-shell particles', Bob W.J. Pirok, Pascal Breuer, Serafine J.M. Hoppe, Mike Chitty, Emmet Welch, Tivadar Farkas, Sjoerd van der Wal, Ron Peters, Peter J. Schoenmakers, Journal of Chromatography A, 1468 (2017) 96-102 doi:10.1016/j.chroma.2016.12.015
  • 'A cyclic-olefin-copolymer microfluidic immobilized-enzyme reactor for rapid digestion of proteins from dried blood spots', Bert Wouters, Irena Dapic, Thalassa S.E. Valkenburg, Sam Wouters, Leon Niezen, Sebastiaan Eeltink, Garry L. Corthals, Peter J. Schoenmakers, Journal of Chromatography A, 1491 (2017) 36-42 doi:10.1016/j.chroma.2017.01.078

Other TI-COAST publications

  • 'Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry', Andreas Nasioudis, Jan W. van Velde, Ron M.A. Heeren, Oscar F. van den Brink, Journal of Chromatography A, 1218 (2011) 7166– 7172 doi:10.1016/j.chroma.2011.08.032.
  • 'Multidimensional Separation of Polymers', Peter Schoenmakers, Petra Aarnoutse, Analytical Chemistry, 86 (2014) 6172-6179 doi:10.1021/ac301162b.
  • 'Identification of Multiple Water-Iodide Species in Concentrated Nal Solutions Based on the Raman Bending Vibration of Water', Matthieu Besemer, Rob Bloemenkamp, Freek Ariese, Henk-Jan van Manen, Journal of Physical Chemistry, (2015) doi:10.1021/acs.jpca.5b10102
  • ‘FLOOD: Flow cytometric orthogonal orientation for diagnosis’, Jeroen  J.  Jansen,  Bart  Hilvering,  Andre  van  den  Doel,  Peter  Pickkers, Leo Koenderman, Lutgarde M.C. Buydens, Oscar F. van den Brink, Chemometrics and Intelligent Laboratory Systems, 151 (2016) 126-135  doi:10.1016/j.chemolab.2015.12.001